Intrathecal morphine as sole analgesic during labour.

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Intrathecal morphine as sole analgesic during labour.

In 12 consecutive unselected patients admitted to a consultant maternity unit one single injection of subarachnoid morphine sulphate 1.5 mg abolished pain during the first stage of labour. Pain in the second stage was abolished in four patients and lessened in three. During the early puerperium, pain at the site of the episitotomy was much reduced. Side effects included itching of the face, nau...

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Intrathecal morphine reduces breakthrough pain during labour epidural analgesia.

BACKGROUND When using the combined spinal-epidural (CSE) technique for labour analgesia, parturients often experience breakthrough pain after the spinal medication has receded. We tested the hypothesis that a small dose of intrathecal morphine would reduce breakthrough pain. METHODS This was a randomized, double-blind, placebo-controlled trial. Subjects were randomized to receive either 100 m...

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OBSTETRICS Intrathecal morphine reduces breakthrough pain during labour epidural analgesia

Methods. This was a randomized, double-blind, placebo-controlled trial. Subjects were randomized to receive either 100 mg of morphine (MS) or placebo (PLCB) with the spinal injection of bupivacaine and fentanyl. Assessments included need for supplementation during labour analgesia, use of pain medications for 24 h after delivery, and side-effects. The primary endpoint was the rate of breakthrou...

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Intrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats

Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...

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Use of PCA morphine as the sole analgesic for postoperative pain relief after TAH.

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ژورنال

عنوان ژورنال: BMJ

سال: 1980

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.281.6236.351